Endocrine Abstracts

The retinoic acid receptor gamma (RARg, encoded by NR1B3/RARG) is significantly downregulated but not mutated in the MSKCC and PRAD prostate cancer (PCa) cohorts in the Cancer Genome Atlas (TCGA) data. We investigated the consequences of modifying RARg expression.Independent of ligand, stable RARg knockdown stimulated RWPE-1 and LNCaP cells proliferation, changed the cell cycle profile and significantly altered global gene expression patterns th...

The corepressor NCOR2/SMRT regulates multiple nuclear receptors (NRs) and other transcription factors. Disruption to these functions are implicated in prostate cancer (PCa) progression but the details remain enigmatic. Therefore we sought to define the global functions of NCOR2/SMRT using isogenic PCa cell models, PCa mouse models and human PCa cohorts.We mapped the NCOR2 dependent transcriptome (RNA-seq), miRnome (miRNA-seq), methylome (EPIC methylation...